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Science 14 February 1969:
Vol. 163. no. 3868, pp. 683 - 685
DOI: 10.1126/science.163.3868.683
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Articles

Fluorescence Changes during Conduction in Nerves Stained with Acridine Orange

I. Tasaki 1, L. Carnay 1, R. Sandlin 1, and A. Watanabe 2

1 Laboratory of Neurobiology, Naztional In. stitutte of Mental Health, Bethesda, Maryland 20014
2 Tokyo Medical and Denttal University, Tokyo, Japan

Nerves from spider crabs anid squid fluoresce when staiined with Acridine Orange. The intenisity of fluorescence increases during nerse conduction. Prolongation of the electric response in the squid axon is associated with a fluorescence change of similar duration. These findings suggest that the physicochemical properties of the macromolecules around the dye molecules in the nerve membrane drastically change during the process of nerve conduction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Changes in Extrinsic Fluorescence in Squid Axons during Voltage-Clamp.
F. Conti and I. Tasaki (1970)
Science 169, 1322-1324
   Abstract »    PDF »
Turbidity, Birefringence, and Fluorescence Changes in Skeletal Muscle Coincident with the Action Potential.
L. D. Carnay and W. H. Barry (1969)
Science 165, 608-609
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)