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Science 14 February 1969:
Vol. 163. no. 3868, pp. 680 - 681
DOI: 10.1126/science.163.3868.680
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Articles

Condylactis Toxin: Interaction with Nerve Membrane Ionic Conductances

Toshio Narahashi 1, John W. Moore 1, and Bert I. Shapiro 2

1 Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina
2 Biological Laboratories, Harvard University, Cambridge, Massachusetts

A toxin from the Bermuda anemone Condylactis gigantea causes the early transient conductance change of crayfish giant axon membranes to persist without affecting the shape of its turning-on. The increase in late steadystate conductance is either not affected or slightly suppressed. The effect on the conductance components can adequately account for the prolonged action potential observed in the treated axon.


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