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Science 31 January 1969:
Vol. 163. no. 3866, pp. 472 - 473
DOI: 10.1126/science.163.3866.472
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Articles

Secretory Activity and Oncogenicity of a Cell Line (MDCK) Derived from Canine Kidneyand

Joseph Leighton 1, Zbynek Brada 1, Larry W. Estes 1, and Gerald Justh 1

1 Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

A cell line (MDCK) of dog kidney origin grows on a glass surface as a mosaic of epithelium with many multicellular hemispherical vesicles. The cells lining the blisters actively secrete into the cyst cavities. Suspensions of these cells injected intravenously in the chick embryo produce brain metastases resembling adenocarcinoma.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)