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Science 10 January 1969:
Vol. 163. no. 3863, pp. 188 - 190
DOI: 10.1126/science.163.3863.188
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Articles

Hemophilia: Role of Organ Homografts

T. L. Marchioro 1, C. Hougie 1, H. Ragde 1, R. B. Epstein 1, and E. D. Thomas 1

1 University of Washington School of Medicine, Departments of Surgery, Pathology, and Medicine, Seattle 98105

The concentration of factor VIII and partial thromboplastin times became normal and have remained normal for 140 days after orthotopic tranplantation of a normal liver to a hemophilic dog. Transplantation of a normal spleen into a hemophilic recipient did not result in a significant increase in factor VIII although the splenic graft was viable for at least 47 days. Transplantation of normal marrow to a lethally irradiated hemophilic dog did not result in an increase in factor VIII during 34 days of observation.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)