Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 December 1968:
Vol. 162. no. 3861, pp. 1494 - 1495
DOI: 10.1126/science.162.3861.1494
Prev | Table of Contents | Next

Articles

lmmunologic Enhancement of Tumor Xenografts by Pepsin-Degraded Immunoglobulin

Samuel Broder 1 and Frank Whitehouse Jr. 1

1 Department of Microbiology, University of Michigan, Ann Arbor

The serums from guinea pigs previously injected with mouse Ehrlich ascites tumor cells were fractionated to obtain ggr2-immunoglobulin. This immunoglobulin was degraded with pepsin to obtain an F(ab')2 fragment. Fresh tumor cells were incubated with immunoglobulin or the fragment and injected into normal guinea pigs. The growth of these cells as tumor xenografts was inhibited by the ggr2-immunoglobulin and enhanced by the F(ab')2 fragment. Similar incubation of tumor cells with normal guinea pig ggr2-globulin or its derived F(ab')2 fragment did not alter subsequent tumor growth.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of Renal Allograft Rejection: Instances in Dogs With Specific Enhancing Immunoglobulin and Its Proteolytic Fragments.
R. H. Yonemoto, R. M. Deliman, W. D. DuSold, and T. Hamilton (1973)
Arch Surg 107, 390-394
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)