Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 20 December 1968:
Vol. 162. no. 3860, pp. 1396 - 1397
DOI: 10.1126/science.162.3860.1396

Articles

Alpha-Chain Disease: A New Immunoglobulin Abnormality

Maxime Seligmann 1, Françoise Danon 1, Daniel Hurez 1, Edith Mihaesco 1, and Jean-Louis Preud'homme 1

1 Research Institute on Blood Diseases, Hôpital Saint-Louis, Paris 10e, France

A new type of pathological immunoglobulin was found in the serum, urine, and saliva of a young Arab patient with abdominal lymphoma and diffuse lymphoplasmacytic infiltration of the small intestine. This protein is devoid of light chains and is closely related to the alpha polypeptide chains of the ggrA1 (Le) subclass of immunoglobulin A. It is characterized by electrophoretic heterogeneity, tendency toward polymerization, and a high carbohydrate content. No intracellular synthesis of light chain was detected.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An approach to duodenal biopsies.
S Serra and P A Jani (2006)
J. Clin. Pathol. 59, 1133-1150
   Abstract »    Full Text »    PDF »
Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation.
F. Suarez, O. Lortholary, O. Hermine, and M. Lecuit (2006)
Blood 107, 3034-3044
   Abstract »    Full Text »    PDF »
Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms.
T. Al-Saleem and H. Al-Mondhiry (2005)
Blood 105, 2274-2280
   Abstract »    Full Text »    PDF »
Changing epidemiology of IPSID in Southern Iran.
K B Lankarani, S M Masoompour, M B Masoompour, R Malekzadeh, S Z Tabei, and M Haghshenas (2005)
Gut 54, 311-312
   Full Text »    PDF »
Immunoproliferative Small Intestinal Disease Associated with Campylobacter jejuni.
M. Lecuit, E. Abachin, A. Martin, C. Poyart, P. Pochart, F. Suarez, D. Bengoufa, J. Feuillard, A. Lavergne, J. I. Gordon, et al. (2004)
N. Engl. J. Med. 350, 239-248
   Abstract »    Full Text »    PDF »
Screening the Cucumber Germplasm Collection for Fruit Yield and Quality.
N. V. Shetty and T. C. Wehner (2002)
Crop Sci. 42, 2174-2183
   Abstract »    Full Text »    PDF »
Immunoglobulin M Heavy Chain Disease: Intracellular Origin of the Mu Chain Fragment.
J. Buxbaum, E. C. Franklin, and M. D. Scharff (1970)
Science 169, 770-773
   Abstract »    PDF »



ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)