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Science 20 December 1968:
Vol. 162. no. 3860, pp. 1396 - 1397
DOI: 10.1126/science.162.3860.1396
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Articles

Alpha-Chain Disease: A New Immunoglobulin Abnormality

Maxime Seligmann 1, Françoise Danon 1, Daniel Hurez 1, Edith Mihaesco 1, and Jean-Louis Preud'homme 1

1 Research Institute on Blood Diseases, Hôpital Saint-Louis, Paris 10e, France

A new type of pathological immunoglobulin was found in the serum, urine, and saliva of a young Arab patient with abdominal lymphoma and diffuse lymphoplasmacytic infiltration of the small intestine. This protein is devoid of light chains and is closely related to the alpha polypeptide chains of the ggrA1 (Le) subclass of immunoglobulin A. It is characterized by electrophoretic heterogeneity, tendency toward polymerization, and a high carbohydrate content. No intracellular synthesis of light chain was detected.


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