Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 December 1968:
Vol. 162. no. 3859, pp. 1290 - 1292
DOI: 10.1126/science.162.3859.1290
Prev | Table of Contents | Next

Articles

Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine

E. Leong Way 1, Horace H. Loh 1, and Fu-hsiung Shen 1

1 Department of Pharmacology, University of California Medical Center, San Francisco 94122

Tolerance and physical dependence development to morphine in mice can be prevented by concomitant administration of cycloheximide. The fact that the rate of synthesis of brain 5-hydroxytryptamine (5HT) increases with tolerance to morphine suggests that the protein involved may be associated with 5HT synthesis. Inhibition of this synthesis with p-chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward.
Z.-Q. Zhao, Y.-J. Gao, Y.-G. Sun, C.-S. Zhao, R. W. Gereau IV, and Z.-F. Chen (2007)
PNAS 104, 14519-14524
   Abstract »    Full Text »    PDF »
Splenic macrophages and B cells mediate immunosuppression following abrupt withdrawal from morphine.
R. T. Rahim, J. J. Meissler Jr., M. W. Adler, and T. K. Eisenstein (2005)
J. Leukoc. Biol. 78, 1185-1191
   Abstract »    Full Text »    PDF »
Morphine Withdrawal Contributes to Th Cell Differentiation by Biasing Cells Toward the Th2 Lineage.
J. Kelschenbach, R. A. Barke, and S. Roy (2005)
J. Immunol. 175, 2655-2665
   Abstract »    Full Text »    PDF »
Modulations of Spinal Serotonin Activity Affect the Development of Morphine Tolerance.
J.-Y. Li, C.-H. Wong, E. Y.-K. Huang, Y.-C. Lin, Y.-L. Chen, P. P. C. Tan, and J.-C. Chen (2001)
Anesth. Analg. 92, 1563-1568
   Abstract »    Full Text »    PDF »
Cotreatment with Racemic Fenfluramine Inhibits the Development of Tolerance to Morphine Analgesia in Rats.
R. H. Arends, T. G. Hayashi, T. J. Luger, and D. D. Shen (1998)
J. Pharmacol. Exp. Ther. 286, 585-592
   Abstract »    Full Text »
Narcotic Drugs: Effects on the Serotonin Biosynthetic Systems of the Brain.
S. Knapp and A. J. Mandell (1972)
Science 177, 1209-1211
   Abstract »    PDF »
Rubidium and Lithium: Opposite Effects on Amine-Mediated Excitement.
B. J. Carroll and P. T. Sharp (1971)
Science 172, 1355-1357
   Abstract »    PDF »
Narcotic Tolerance and Dependence: Lack of Relationship with Serotonin Turnover in the Brain.
D. L. Cheney, A. Goldstein, S. Algeri, and E. Costa (1971)
Science 171, 1169-1170
   Abstract »    PDF »
Catecholamine Biosynthesis in Brains of Rats Treated with Morphine.
D. H. Clouet and M. Ratner (1970)
Science 168, 854-856
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)