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Science 13 December 1968:
Vol. 162. no. 3859, pp. 1277 - 1279
DOI: 10.1126/science.162.3859.1277
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Articles

Deficiency of Reduced Nicotinamide-Adenine Dinucleotide Oxidase in Chronic Granulomatous Disease

Robert L. Baehner 1 and Manfred L. Karnovsky 2

1 Department of Medicine, Division of Research Hematology, Children's Hospital Medical Center, Boston, Massachusetts
2 Department of Biological Chemistry, Harvard Medical School, Boston

Reduced nicotinamide-adenine dinucleotide oxidase of normal human polymorphonuclear leukocytes has properties that would qualify it as the enzyme responsible for the respiratory burst during phagocytosis. The enzyme was deficient in leukocytes of five patients with chronic granulomatous disease. This lack of adequate reduced nicotinamide-adenine dinucleotide oxidase could be the basis for the metabolic abnormalities characteristic of these leukocytes and for their diminished bactericidal activity.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)