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Science 6 December 1968:
Vol. 162. no. 3858, pp. 1132 - 1134
DOI: 10.1126/science.162.3858.1132
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Articles

Erythropoiesis in the Rat: Differential Rates of DNA Synthesis and Cell Proliferation

Francis C. Monette 1, Joseph LoBue 1, Albert S. Gordon 1, Peter Alexander Jr. 1, and Po-Chuen Chan 2

1 Department of Biology, Graduate School of Arts and Science, New York University, New York 10003
2 Sloan-Kettering Institute for Cancer Research, New York

Direct in vivo estimates of DNA synthesis time in early and late erythroblasts were obtained by using the H3- and C14-thymidine double-la-beling technique. A double-emulsion autoradiographic procedure was used to resolve the two isotopes. Early erythroblasts were found to proliferate at a rate about five times that of late cells. This results primarily from a shorter mean DNA synthesis time in early cells (2.5 hours) than in late cells (6.5 hours).

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Science. ISSN 0036-8075 (print), 1095-9203 (online)