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Science 29 November 1968:
Vol. 162. no. 3857, pp. 1011 - 1012
DOI: 10.1126/science.162.3857.1011
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Articles

Morphine: Single-Dose Tolerance

Conan Kornetsky 1 and George Bain 1

1 Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118

Rats show a significant degree of tolerance to a second dose of morphine, with the degree of tolerance increasing the longer the delay between the two doses of morphine. To measure the morphine effect a foot-shock attenuation procedure that allowed the animal to adjust the shock intensity was used in studying delays of up to 180 days.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Morphine Tolerance: Is There Evidence for a Conditioning Model?.
S. SIEGEL (1978)
Science 200, 344-345
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Time-dependent disruption of morphine tolerance by electroconvulsive shock and frontal cortical stimulation.
R. Kesner, D. Priano, and DeWitt JR (1976)
Science 194, 1079-1081
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Nalorphine: increased sensitivity of monkeys formerly dependent on morphine..
S. R. Goldberg and C. R. Schuster (1969)
Science 166, 1548-1549
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)