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Science 29 November 1968:
Vol. 162. no. 3857, pp. 1001 - 1003
DOI: 10.1126/science.162.3857.1001
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Articles

Estradiol-Concentrating Neurons: Topography in the Hypothalamus by Dry-Mount Autoradiography

Walter E. Stumpf 1

1 Department of Pharmacology, University of Chicago, Chicago, Illinois 60637

Serial section autoradiograms were prepared of different planes of the hypothalamus and diencephalon of immature female, immature male, and ovariectomized mature rats injected with 6,7-3H-estradiol-17 beta. Known causes of diffusion and redistribution of the label, such as fixation, embedding, and thawing, were eliminated by the use of an autoradiographic technique based on the dry-mounting of freeze-dried sections. Neurons that concentrate estradiol exist in distinct and definable anatomical areas that are independent of the sex and hormonal state of the animals. Distribution of these neurons follows known terminations of the stria terminalis, which supports the concept of an endocrine amygdaloid-hypothalamic-hypophysial axis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
17{beta}-Estradiol Reduces Stroke Injury in Estrogen-Deficient Female Animals • Editorial Comment.
R. Rusa, N. J. Alkayed, B. J. Crain, R. J. Traystman, A. S. Kimes, E. D. London, J. A. Klaus, P. D. Hurn, and C. Iadecola (1999)
Stroke 30, 1665-1670
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Effects of Estrous Cyclicity on the Expression of the Galanin Receptor Gal-R1 in the Rat Preoptic Area: A Comparison with the Male.
C. Faure-Virelizier, D. Croix, S. Bouret, V. Prevot, S. Reig, J.-C. Beauvillain, and V. Mitchell (1998)
Endocrinology 139, 4127-4139
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Estrogen-Mediated Neuroprotection After Experimental Stroke in Male Rats • Editorial Comment.
T. J. K. Toung, R. J. Traystman, P. D. Hurn, and V. M. Miller (1998)
Stroke 29, 1666-1670
   Abstract »    Full Text »    PDF »
Gender-Linked Brain Injury in Experimental Stroke • Editorial Comment.
N. J. Alkayed, I. Harukuni, A. S. Kimes, E. D. London, R. J. Traystman, P. D. Hurn, and P. A. Grady (1998)
Stroke 29, 159-166
   Abstract »    Full Text »    PDF »
Estradiol is concentrated in tyrosine hydroxylase-containing neurons of the hypothalamus.
M Sar (1984)
Science 223, 938-940
   Abstract »    PDF »
Brain target sites for 1,25-dihydroxyvitamin D3.
W. Stumpf, M Sar, S. Clark, and H. DeLuca (1982)
Science 215, 1403-1405
   Abstract »    PDF »
Sexual Difference in Pattern of Hormone Accumulation in the Brain of a Songbird.
A. P. ARNOLD and A. SALTIEL (1979)
Science 205, 702-705
   Abstract »    PDF »
Testosterone reduces refractory period of stria terminalis neurons in the rat brain.
K. Kendrick and R. Drewett (1979)
Science 204, 877-879
   Abstract »    PDF »
Neurons of the Hypothalamus Concentrate [3H]Progesterone or Its Metabolites.
M. Sar and W. E. Stumpf (1973)
Science 182, 1266-1268
   Abstract »    PDF »
Testosterone Concentration in the Male Chick Brain: An Autoradiographic Survey.
C. C. Meyer (1973)
Science 180, 1381-1383
   Abstract »    PDF »
Activation of Lordotic Responding in Female Rats by Suppression of Serotonergic Activity.
F. P. Zemlan, I. L. Ward, W. R. Crowley, and D. L. Margules (1973)
Science 179, 1010-1011
   Abstract »    PDF »
Pituitary Gonadotrophs: Nuclear Concentration of Radioactivity after Injection of [3H]Testosterone.
M. Sar and W. E. Stumpf (1973)
Science 179, 389-391
   Abstract »    PDF »
Rat Brain Binds Adrenal Steroid Hormone: Radioautography of Hippocampus with Corticosterone.
J. L. Gerlach and B. S. McEwen (1972)
Science 175, 1133-1136
   Abstract »    PDF »
EEG Responses in Regularly Menstruating Women and in Amenorrheic Women Treated with Ovarian Hormones.
W. Vogel, D. M. Broverman, and E. L. Klaiber (1971)
Science 172, 388-391
   Abstract »    PDF »
Intracranial Drug Implants: An Autoradiographic Analysis of Diffusion.
S. P. Grossman and W. E. Stumpf (1969)
Science 166, 1410-1412
   Abstract »    PDF »
Estradiol: Specific Binding by Pituitary Nuclear Fraction in vitro.
W. W. Leavitt, J. P. Friend, and J. A. Robinson (1969)
Science 165, 496-498
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