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Science 22 November 1968:
Vol. 162. no. 3856, pp. 917 - 918
DOI: 10.1126/science.162.3856.917
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Articles

Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding

Charles S. Lieber 1 and Leonore M. DeCarli 1

1 Section of Liver Disease and Nutrition, Veterans Administration Hospital, Bronx, New York 10468, and Department of Medicine, Mount Sinai School of Medicine, City University of New York, New York

Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol. The existence of this microsomal ethanol-oxidizing system may explain ultrastructural, pharmacological, and biochemical effects of ethanol.


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