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Science 22 November 1968:
Vol. 162. no. 3856, pp. 905 - 907
DOI: 10.1126/science.162.3856.905
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Articles

Genetic Polymorphism of C'3(beta1c-Globuiin) in Human Serum

Edwin A. Azen 1 and Oliver Smithies 2

1 Department of Medicine, University of Wisconsin, Madison 53706
2 Laboratory of Genetics, University of Wisconsin

Genetic polymorphism of the third component of human complement and its breakdown products has been detected in human serum by high-voltage starch-gel electrophoresis. Six phenotypes were observed in a study of 113 randomly chosen Caucasians. Their inheritance is controlled by four codominant alleles at an autosomal locus. The gene frequencies in this study were C31, 0.21; C32, 0.77; C33, sim0.01; and C34, sim0.004.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Complement C3 Variant and the Risk of Age-Related Macular Degeneration.
J. R.W. Yates, T. Sepp, B. K. Matharu, J. C. Khan, D. A. Thurlby, H. Shahid, D. G. Clayton, C. Hayward, J. Morgan, A. F. Wright, et al. (2007)
N. Engl. J. Med. 357, 553-561
   Abstract »    Full Text »    PDF »
Human C'3: Evidence for the Liver as the Primary Site of Synthesis.
C. A. Alper, A. M. Johnson, A. G. Birtch, and F. D. Moore (1969)
Science 163, 286-288
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)