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Science 8 November 1968:
Vol. 162. no. 3854, pp. 690 - 691
DOI: 10.1126/science.162.3854.690
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Articles

Hepatic Microsomal Enzymes in Man and Rat: Induction and Inhibition by Ethanol

Emanuel Rubin 1 and Charles S. Lieber 2

1 Department of Pathology, Mount Sinai School of Medicine, City University of New York, New York 10029
2 Section of Liver Disease and Nutrition, Bronx Veterans Administration Hospital, and Department of Medicine, Mount Sinai School of Medicine

The feeding of ethanol increased significantly the activities of hepatic pentobarbital and benzpyrene hydroxylases in rats, and, in human volunteers, doubled pentobarbital hydroxylase activity. In vitro ethanol inhibited aniline, pentobarbital, and benzpyrene hydroxylases. These data may explain, at least in part, the increased tolerance of alcoholics to sedatives when sober, and the enhanced sensitivity to sedatives when inebriated.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)