Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 8 November 1968:
Vol. 162. no. 3854, pp. 679 - 681
DOI: 10.1126/science.162.3854.679
Prev | Table of Contents | Next

Articles

Genetic Implications of Common Region Sequence Comparisons of Lambda Immunoglobulin Chains Differing at Position 190

Leroy Hood 1 and Daniel Ein 1

1 National Cancer Institute, Bethesda, Maryland 20014

The common regions of two lambda chains (amino acid residues 109 to 213) have been partially sequenced. These two human immunoglobulin chains have lysine at position 190, but are otherwise identical in their common-region sequence to four reported lambda chains that have arginine at position 190. The single amino acid interchange at position 190 may be explained either by an ambiguous codon at this position or by a gene duplication so recent that only a single mutational event has occured.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation.
C. Markert, J. Shaklee, and G. Whitt (1975)
Science 189, 102-114
   PDF »
Creation of "Amyloid" Fibrils from Bence Jones Proteins in vitro.
G. G. Glenner, D. Ein, E. D. Eanes, H. A. Bladen, W. Terry, and D. L. Page (1971)
Science 174, 712-714
   Abstract »    PDF »
Familial Paraproteinemia.
J. A. Grant, G. R. Blumenschein, and C. E. Buckley III (1971)
Arch Intern Med 128, 427-431
   Abstract »    PDF »
Mechanism of Antibody Diversity: Germ Line Basis for Variability.
L. Hood and D. W. Talmage (1970)
Science 168, 325-334
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)