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Science 8 November 1968:
Vol. 162. no. 3854, pp. 672 - 673
DOI: 10.1126/science.162.3854.672
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Articles

C'3 Synthesis in the Human Fetus and Lack of Transplacental Passage

Richard P. Propp 1 and Chester A. Alper 1

1 Blood Grouping Laboratory and Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts

Allotypic differences in the third component of complement between mothers and their newborns provided evidence for synthesis of this complement component by the fetus. There was no indication that this protein traversed the placenta. The known low level of C'3 in the neonate was confirmed, and the maternal concentration was found to be significantly elevated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Influence of Age and Sex on Serum Complement Components in Children.
B. Roach, Y. Kim, E. Jerome, and A. F. Michael (1981)
Arch Pediatr Adolesc Med 135, 918-920
   Abstract »    PDF »
Human Complement: Onset and Site of Synthesis During Fetal Life.
M. Adinolfi (1977)
Arch Pediatr Adolesc Med 131, 1015-1023
   Abstract »    PDF »
Leukocyte Function and the Development of Opsonic and Complement Activity in the Neonate.
G. H. McCracken Jr. and H. F. Eichenwald (1971)
Arch Pediatr Adolesc Med 121, 120-126
   Abstract »    PDF »
Human C'3: Evidence for the Liver as the Primary Site of Synthesis.
C. A. Alper, A. M. Johnson, A. G. Birtch, and F. D. Moore (1969)
Science 163, 286-288
   Abstract »    PDF »


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