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Science 1 November 1968:
Vol. 162. no. 3853, pp. 574 - 576
DOI: 10.1126/science.162.3853.574
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Articles

Imnunoglobulin M Antibodies with Ten Combining Sites

K. Onoue 1, A. L. Grossberg 1, Y. Yagi 1, and D. Pressman 1

1 Department of Biochemistry Research, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, N. Y. 14203

Immunoglobulin M rabbit antibodies to a hapten are shown to have ten binding sites per molecule. The affinity for the specific hapten is approximately 100 times greater for one-half of the sites than for the other half. All sites are retained in the five 7S subunits produced by reduction and alkylation of the immunoglobulin M. Each of the 7S subunits of the IgM molecule apparently has one strong and one weak site.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Macroglobulin Structure: Variable Sequence of Light and Heavy Chains.
H. Kohler, A. Shimizu, C. Paul, and F. W. Putnam (1970)
Science 169, 56-59
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Science. ISSN 0036-8075 (print), 1095-9203 (online)