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Science 1 November 1968:
Vol. 162. no. 3853, pp. 570 - 572
DOI: 10.1126/science.162.3853.570
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Articles

Hurler and Hunter Syndromes: Mutual Correction of the Defect in Cultured Fibroblasts

Joseph C. Fratantoni 1, Clara W. Hall 1, and Elizabeth F. Neufeld 1

1 National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

The biochemical defect of cultuired skin fibroblasts from Hurler or Hunter patients (faulty degradation of sulfated mucopolysaccharide, resulting in excessive intracellular accumulation) may be corrected if cells of these two genotypes are mixed with each other or with normal cells. The effect is mediated by substances released into the medium.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)