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Science 1 November 1968:
Vol. 162. no. 3853, pp. 565 - 567
DOI: 10.1126/science.162.3853.565
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Articles

Reticuloendothelial Blockade: Effect of Puromycin on Opsonin-Dependent Recovery

J. C. Pisano 1, J. T. Patterson 1, and N. R. Di Luzio 1

1 Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112

Reticuloendothelial blockade induced by the administration of a gelatinized "reticuloendothelial test lipid emulsion" is due to a loss of opsonic activity in the plasma. Recovery from blockade, which is associated with restoration of plasma opsonins, was inhibited by the administration of puromycin. The effect of puromycin appears to be mediated by inhibition of opsonin formation rather than a puromycin-induced macrophage defect in phagocytosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Physiology and Physiopathology of the Reticuloendothelial System.
T. M. Saba (1970)
Arch Intern Med 126, 1031-1052
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