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Science 1 November 1968:
Vol. 162. no. 3853, pp. 564 - 565
DOI: 10.1126/science.162.3853.564
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Articles

Mutant S1 Alleles of Mice Affect Susceptibility to Friend Spleen Focus-Forming Virus

M. Bennett 1, R. A. Steeves 1, G. Cudkowicz 1, E. A. Mirand 1, and L. B. Russell 2

1 Departments of Experimental Biology and Viral Oncology, Roswell Park Memorial Institute, Buffalo, New York 14203
2 Oak Ridge National Laboratory, Biology Division, Oak Ridge, Tennessee 37831

Mice of genotypes S1/S1d, S1/+, and S1d/+ (but not S1T/S1T or S1T/+) were resistant to spleen focucs-forming virus. The "environment" in which hemopoietic target cells for this virus develop was not conducive for infection or focus formation, or both, but the target cells were not altered directly. The same genes appear to regulate hemopoiesis and leukemogenic transformation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Friend Virus Utilizes the BMP4-Dependent Stress Erythropoiesis Pathway To Induce Erythroleukemia.
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J. Virol. 82, 382-393
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Resistance to Friend Virus-Induced Erythroleukemia in W/Wv Mice Is Caused by a Spleen-Specific Defect Which Results in a Severe Reduction in Target Cells and a Lack of Sf-Stk Expression.
A. Subramanian, H. E. Teal, P. H. Correll, and R. F. Paulson (2005)
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Friend erythroleukemia revisited.
P. A. Ney and A. D. D'Andrea (2000)
Blood 96, 3675-3680
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Host Control of Sequences Specific to Friend Erythroleukemia Virus in Normal and Leukemic Mice.
T. W. Mak, C. L. Gamble, M. E. MacDonald, and A. Bernstein (1980)
Cold Spring Harb Symp Quant Biol 44, 893-899
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