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Science 1 November 1968:
Vol. 162. no. 3853, pp. 560 - 561
DOI: 10.1126/science.162.3853.560
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Articles

Ouabain Hypoglycemia: Insulin Mediation

L. Triner 1, Paul Killian 1, and G. G. Nahas 1

1 Departments of Anesthesiology and Medicine, College of Physicians and Surgeons, Columbia University, New York 10032

The fall in blood sugar occurring during infusion of ouabain (1 microgram per kilogram per minute for a 60-minute period) in dogs is accompanied by an increased uptake of glucose and potassium by the liver. Concurrently, plasma insulin in the portal blood increases significantly. This increase appears to be a result of increased insulin secretion caused by ouabain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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M. Kajikawa, S. Fujimoto, Y. Tsuura, E. Mukai, T. Takeda, Y. Hamamoto, M. Takehiro, J. Fujita, Y. Yamada, and Y. Seino (2002)
Diabetes 51, 2522-2529
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Sodium/Calcium Exchange: Its Physiological Implications.
M. P. Blaustein and W. J. Lederer (1999)
Physiol Rev 79, 763-854
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