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Science 18 October 1968:
Vol. 162. no. 3851, pp. 369 - 371
DOI: 10.1126/science.162.3851.369
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Articles

Three IgA Myeloma Immunoglobulins from the BALB/c Mouse: Precipitation with Pneumococcal C Polysaccharide

Michael Potter 1 and Myron A. Leon 2

1 Laboratory of Biology, National Cancer Institute, Bethesda, Maryland 20014
2 Department of Pathology Research, St. Luke's Hospital, Cleveland, Ohio

Three of 64 IgA immunoglobuilins, derived from plasma cell tumors induced by mineral oil in BALB/c mice, precipitated with species-specific pneumococcus C polysaccharide. A related antigen was also found in group O and some group H streptococci. A difference in ability to precipitate a C polysaccharide from a pneumococcus type XIV was demonstrated between protein 603 which did precipitate and protein 167 which did not precipitate this polysaccharide. Studies of the 167 and 603 proteins showed differences in electrophoretic mobility and polypeptide chains. The antigen-combining site of the 167 and 603 proteins resided on the papain-digestion Fab fragment.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Monoclonal Antibodies: Producing Magic Bullets by Somatic Cell Hybridization.
D. H. Margulies (2005)
J. Immunol. 174, 2451-2452
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Primary Structural Differences in Myeloma Proteins That Bind the Same Haptens.
M. Potter, S. Rudikoff, M. Vrana, D. N. Rao, and E. B. Mushinski (1977)
Cold Spring Harb Symp Quant Biol 41, 661-666
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Imunoglobulin Structure: Amino Terminal Sequences of Mouse Myeloma Proteins That Bind Phosphorylcholine.
P. Barstad, S. Rudikoff, M. Potter, M. Cohn, W. Konigsberg, and L. Hood (1974)
Science 183, 962-964
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Specific Suppression of Immune Responses.
D. A. Rowley, F. W. Fitch, F. P. Stuart, H. Kohler, and H. Cosenza (1973)
Science 181, 1133-1141
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Specific Inhibition of Plaque Formation to Phosphorylcholine by Antibody against Antibody.
H. Cosenza and H. Kohler (1972)
Science 176, 1027-1029
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Antigenicity: Some Molecular Aspects.
M. Sela (1969)
Science 166, 1365-1374
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Affinity Site Labeling of a Mouse Myeloma Protein Which Binds Dinitrophenyl Ligands.
H. Metzger and M. Potter (1968)
Science 162, 1398-1400
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Science. ISSN 0036-8075 (print), 1095-9203 (online)