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Science 18 October 1968:
Vol. 162. no. 3851, pp. 361 - 363
DOI: 10.1126/science.162.3851.361
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Articles

Chemotactic and Anaphylatoxic Fragment Cleaved from the Fifth Component of Guinea Pig Complement

Hyun S. Shin 1, Ralph Snyderman 2, Eileen Friedman 3, Alice Mellors 3, and Manfred M. Mayer 3

1 Department of Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
2 Laboratory of Microbiology, National Institute of Dental Research, Bethesda, Maryland
3 Department of Microbiology, Johns Hopkins University School of Medicine

The fifth component of guinea pig complement, with a sedimentation coefficient 7.8S, is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4S and 1.5S. The smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig ileum.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)