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Science 11 October 1968:
Vol. 162. no. 3850, pp. 283 - 284
DOI: 10.1126/science.162.3850.283
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Articles

Insulin Secretion from Toadfish Islet Tissue Stimulated by Pyridine Nucleotides

D. Watkins 1, S. J. Cooperstein 1, P. K. Dixit 2, and A. Lazarow 2

1 Department of Anatomy, University of Connecticut Schools of Medicine and Dental Medicine, Storrs 06268 and Marine Biological Laboratory, Woods Hole, Massachusetts
2 Department of Anatomy, University of Minnesota School of Medicine, Minneapolis 55455, and Marine Biological Laboratory, Woods Hole, Massachusetts

The addition of glucose stimulated release of insulin from the isolated islet tissue of the toadfish incubated in vitro. Reduced nicotinamide-adenine dinucleotide also stimulated insulin release, whereas the oxidized form had no effect. Both oxidized and reduced nicotinamide-adenine dinucleatide phosphate stimulated insulin release, but the reduced form was significantly more effective.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Malate-Aspartate NADH Shuttle Member Aralar1 Determines Glucose Metabolic Fate, Mitochondrial Activity, and Insulin Secretion in Beta Cells.
B. Rubi, A. del Arco, C. Bartley, J. Satrustegui, and P. Maechler (2004)
J. Biol. Chem. 279, 55659-55666
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Science. ISSN 0036-8075 (print), 1095-9203 (online)