Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 October 1968:
Vol. 162. no. 3849, pp. 131 - 132
DOI: 10.1126/science.162.3849.131
Prev | Table of Contents | Next

Articles

Brain Alcohol Dehydrogenase

Neil H. Raskin 1 and Louis Sokoloff 1

1 Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014

Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural disorders associated with chronic alcohol ingestion or withdrawal.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction.
V. E. I and M. J. M (1970)
Science 167, 1005-1007
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)