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Science 4 October 1968:
Vol. 162. no. 3849, pp. 127 - 128
DOI: 10.1126/science.162.3849.127
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Articles

Human Prothrombin Activation: Immunochemical Study

Sandor S. Shapiro 1

1 Cardeza Foundation for Hematologic Research, Department of Medicine. Jeffersont Medical College, Philadelphia, Pennsylvania 19107

Antiserums to human prothrontbin contain antibodies directed against at least two different antigenic sites. During blood coagulation, prothrombin is cleaved into two major antigenically distinct fragments-thrombin and a "pro" fragment. The latter is present in normal seruim, whereas thrombin loses its immunologic reactivity, presumably because of its combination with the natural thrombin inhibitors in blood.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)