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Science 4 October 1968:
Vol. 162. no. 3849, pp. 126 - 127
DOI: 10.1126/science.162.3849.126
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Articles

Herpes Simplex Virus in Mice: Electron Microscopy of Neural Spread

Erwin R. Rabin 1, A. Bennett Jenson 1, and Joseph L. Melnick 1

1 Departments of Pathology and Virology anid Epidemiology, Baylor University College of Medicine, Houston, Texas

Herpes simplex virus rapidly infected the trigeminal nerves of mice after intranasal inoculation. Centripetal neural spread was suggested by histologic evidence of encephalitis in the area of attachment of the trigeminal nerve. Furthermore, electron microscopy revealed virus replication primarily within Schwann cells of the trigeminal nerve, and neurons of the gasserian ganglion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lesions Produced by Human Herpesviruses 1 and 2: Morphologic Features in Rabbit Corneal Epithelium.
M. J. Hollenberg, J. S. Wilkie, J. B. Hudson, and B. J. Lewis (1976)
Arch Ophthalmol 94, 127-134
   Abstract »    PDF »
Chronic Herpes Simplex Virus Infection: Initiation in Hamsters Upon Implantation of Infected Nonpermissive Glial Cells.
J. Schwartz and T. S. Elizan (1973)
Arch Neurol 28, 224-230
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)