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Science 27 September 1968:
Vol. 161. no. 3848, pp. 1347 - 1348
DOI: 10.1126/science.161.3848.1347
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Articles

Gaucher's Disease: A Genetic Disease Detected in Skin Fibroblast Cultures

B. Shannon Danes 1 and Alexander G. Bearn 1

1 Division of Human Genetics, Department of Medicine, Cornell University Medical College, New York 10021

Skin fibroblasts from three adult patients with chronic noncerebral Gaucher's disease, three children of one of the patients, three parents, and six normal individuals were grown in cell culture. Giant fibroblasts containing metachromatic material were seen in all cultures derived from affected individuals and heterozygous carriers but not in those derived from normal individuals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Treatment of Genetic Disorders.
S. A. Muller (1975)
Arch Dermatol 111, 1620-1624
   Abstract »    PDF »
Thrombocytopenia in Gaucher's Disease.
D. GREEN, H. A. BATTIFORA, R. T. SMITH, and E. C. ROSSI (1971)
Ann Intern Med 74, 727-731
   Abstract »    PDF »
Myotonic Muscular Dystrophy: Abnormalities in Fibroblast Culture.
M. R. Swift and M. J. Finegold (1969)
Science 165, 294-296
   Abstract »    PDF »
Glycolipid and Mucopolysaccharide Abnormality in Fibroblasts of Fabry's Disease.
R. Matalon, A. Dorfman, G. Dawson, and C. C. Sweeley (1969)
Science 164, 1522-1523
   Abstract »    PDF »


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