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Science 20 September 1968:
Vol. 161. no. 3847, pp. 1255 - 1256
DOI: 10.1126/science.161.3847.1255
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Articles

Herpesvirus Type 2: Association with Carcinoma of the Cervix

W. E. Rawls 1, W. A. F. Tompkins 1, M. E. Figueroa 1, and J. L. Melnick 1

1 Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas 77025

By utilizing the kinetics of neutralization, it was found that an antibody response to type 1 (oral) and type 2 (genital) herpesvirus infection could be independently measured and correlated with type of virus isolated from the patient. The presence of antibodies to type 1 and type 2 herpesvirus was examined in patients with carcinoma of the cervix, in matched controls, random controls, and patients with other types of malignancy. Antibodies to type 2 were found with greater frequency in patients with carcinoma of the cervix (83 percent) than in the other groups tested (0 to 20 percent). The data suggest an association of genital herpesvirus and carcinoma of the cervix.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Herpes Simplex Virus-2 as a Human Papillomavirus Cofactor in the Etiology of Invasive Cervical Cancer.
J. S. Smith, R. Herrero, C. Bosetti, N. Munoz, F. X. Bosch, J. Eluf-Neto, X. Castellsague, C. J. L. M. Meijer, A. J. C. Van den Brule, S. Franceschi, et al. (2002)
J Natl Cancer Inst 94, 1604-1613
   Abstract »    Full Text »    PDF »
Oncogenic transformation of human embryo lung cells by human cytomegalovirus.
K. Geder, R Lausch, F O'Neill, and F Rapp (1976)
Science 192, 1134-1137
   Abstract »    PDF »
Acute Ocular Infection by Type 2 Herpes Simplex Virus in Adults: Report of Two Cases.
J. O. Oh, S. J. Kimura, and H. B. Ostler (1975)
Arch Ophthalmol 93, 1127-1129
   Abstract »    PDF »
Comparison of Types 1 and 2 Herpesvirus hominis Infection of Rabbit Eyes: I. Clinical Manifestations.
J. O. Oh and T. R. Stevens (1973)
Arch Ophthalmol 90, 473-476
   Abstract »    PDF »
Soluble Membrane Antigens of Lip and Cervical Carcinomas: Reactivity with Antibody for Herpesvirus Nonvirion Antigens.
A. C. Hollinshead and G. Tarro (1973)
Science 179, 698-700
   Abstract »    PDF »
Herpesvirus Type 2 Isolated from Cervical Tumor Cells Grown in Tissue Culture.
L. Aurelian, J. D. Strandberg, L. V. Melendez, and L. A. Johnson (1971)
Science 174, 704-707
   Abstract »    PDF »
Herpesvirus Antibody and Carcinoma in Situ of the Cervix.
L. W. Catalano Jr. and L. D. Johnson (1971)
JAMA 217, 447-450
   Abstract »    PDF »
Genital Herpesvirus Hominis Type 2 Infection: An Experimental Model in Cebus Monkeys.
A. J. Nahmias, W. T. London, L. W. Catalano, D. A. Fuccillo, J. L. Sever, and C. Graham (1971)
Science 171, 297-298
   Abstract »    PDF »
Herpesviruses and Cancer.
C. R. Goodheart (1970)
JAMA 211, 91-96
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)