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Science 13 September 1968:
Vol. 161. no. 3846, pp. 1155 - 1157
DOI: 10.1126/science.161.3846.1155
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Articles

Allergic Encephalomyelitis: Passive Transfer Prevented by Encephalitogen

Seymour Levine 1, Eugene M. Hoenig 1, and Marian W. Kies 2

1 Pathology Department, New York Medical College Center for Chronic Disease, Bird S. Coler Hospital, Welfare Island, New York
2 National Institute of Mental Health, Bethesda, Maryland 20014

Allergic encephalomyelitis was produced in rats by passive transfer of lymph node cells from donors immunized intradernmally with nleural tissute or an encephalitogenic basic protein pluts adjulvants. The same basic protein, injected intravenously into the recipients before or after transfer of lymph node cells, prevented the disease. Even established lesions were reversed. Inhibition by basic protein was specific for encephalomyelitis; it had no effect onz passive transfer of allergic adrenalitis.


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