Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 9 August 1968:
Vol. 161. no. 3841, pp. 594 - 595
DOI: 10.1126/science.161.3841.594
Prev | Table of Contents | Next

Articles

Metachromatic Leukodystrophy: Diagnosis with Samples of Venous Blood

Alan K. Percy 1 and Roscoe O. Brady 1

1 National Institute of Neurological Diseases and Blindness, National Institutes of Health, Bethesda, Maryland 20014

Arylsulfatase A and B have been demonstrated in preparations of human leukocytes. The level of activity of arylsulfatase A is markedly decreased in the preparations from patients with metachromatic leukodystrophy. Acid phosphatase and arylsulfatase B activities were normal. The assay of arylsulfatase A in leukocyte preparations can be useful in the diagnosis of metachromatic leukodystrophy while obviating the difficulties of current methods.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Peripheral blood leukocyte NO production and oxidative stress in multiple sclerosis.
M. Koch, J. Mostert, A. Arutjunyan, M. Stepanov, A. Teelken, D. Heersema, and J. De Keyser (2008)
Multiple Sclerosis 14, 159-165
   Abstract »    PDF »
Peripheral blood leukocyte NO production in MS patients with a benign vs progressive course.
G. S.M. Ramsaransing, A. Teelken, A. V. Arutjunyan, and J. De Keyser (2004)
Neurology 62, 239-242
   Abstract »    Full Text »    PDF »
Low leucocyte myeloperoxidase activity in patients with multiple sclerosis.
G Ramsaransing, A Teelken, V M Prokopenko, A. Arutjunyan, and J De Keyser (2003)
J. Neurol. Neurosurg. Psychiatry 74, 953-955
   Abstract »    Full Text »    PDF »
Cooling garment treatment in MS: Clinical improvement and decrease in leukocyte NO production.
E. A.C. Beenakker, T. I. Oparina, A. Hartgring, A. Teelken, A. V. Arutjunyan, and J. De Keyser (2001)
Neurology 57, 892-894
   Abstract »    Full Text »    PDF »
Adult Metachromatic Leukodystrophy: Value of Computed Tomographic Scanning and Magnetic Resonance Imaging of the Brain.
G. Waltz, S. I. Harik, and B. Kaufman (1987)
Arch Neurol 44, 225-227
   Abstract »    PDF »
Congenital Muscle Fiber-Type Disproportion in Krabbe's Leukodystrophy.
F. Dehkharghani, H. B. Sarnat, M. A. Brewster, and S. I. Roth (1981)
Arch Neurol 38, 585-587
   Abstract »    PDF »
Juvenile Metachromatic Leukodystrophy: Clinical, Biochemical, and Neuropathologic Studies in Nine New Cases.
T. Haltia, J. Palo, M. Haltia, and A. Icen (1980)
Arch Neurol 37, 42-46
   Abstract »    PDF »
Monozygotic Twins With Presumed Metachromatic Leukodystrophy: Activity of Arylsulfatase A in Serum of Patients and Family.
T. Hashimoto, H. Minato, Y. Kuroda, K. Toshima, K. Ohara, and M. Miyao (1978)
Arch Neurol 35, 689-691
   Abstract »    PDF »
Late Adult-Onset Metachromatic Leukodystrophy: Dementia and Polyneuropathy in a 63-Year-Old Man.
E. P. Bosch and M. N. Hart (1978)
Arch Neurol 35, 475-477
   Abstract »    PDF »
Skin Punch Biopsy in the Diagnosis of Juvenile Neuronal Ceroid-Lipofuscinosis: A Comparison With Leukocyte Peroxidase Assay.
D. F. Farrell and S. M. Sumi (1977)
Arch Neurol 34, 39-44
   Abstract »    PDF »
Biochemical Genetics in Neurology.
R. O. Brady (1976)
Arch Neurol 33, 145-151
   Abstract »    PDF »
Metachromatic Leukodystrophy: Ultrastructural and Enzymatic Study of a Case of Variant 0 Form.
E.-J. Raynaud, R. Escourolle, N. Baumann, J.-C. Turpin, G. Dubois, G. Malpuech, and R. Lagarde (1975)
Arch Neurol 32, 834-838
   Abstract »    PDF »
Infusion of Normal HL-A Identical Leukocytes in Sanfilippo Disease Type B: Estimate of Infused Cell Survival by Assays of {alpha}-N-Acetylglucosaminidase Activity and Cytogenetic Techniques: Effect on Glycosaminoglycan Excretion in the Urine.
H. W. Moser, J. S. O'Brien, L. Atkins, T. C. Fuller, A. Kliman, S. Janowska, P. S. Russell, C. S. Bartsocas, B. Cosimi, and J. T. Dulaney (1974)
Arch Neurol 31, 329-337
   Abstract »    PDF »
Leigh Disease: Biochemical Characteristics of the Inhibitor.
J. V. Murphy, L. J. Craig, and R. H. Glew (1974)
Arch Neurol 31, 220-227
   Abstract »    PDF »
Late Adult Metachromatic Leukodystrophy: Arylsulfatase A Activity of Leukocytes in Two Families.
H. Pilz (1972)
Arch Neurol 27, 87-90
   Abstract »    PDF »
Chemical Detection of Metachromatic Leukodystrophy in Disease and Carrier States.
T. N. Hackett Jr., R. J. Hackett, P. F. Bray, and J. A. Madsen (1971)
Arch Pediatr Adolesc Med 122, 223-225
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)