Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 August 1968:
Vol. 161. no. 3840, pp. 475 - 476
DOI: 10.1126/science.161.3840.475
Prev | Table of Contents | Next

Articles

Desmosine Biosynthesis: Nature of Inhibition by D-Penicillamine

S. R. Pinnell 1, G. R. Martin 1, and E. J. Miller 1

1 National Institute of Dental Research, Bethesda, Maryland 20014

Administration of D-penicillamine and lathyrogens such as beta-amino-propionitrile to animals markedly alters connective tissue by preventing the normal cross-linkage of elastin and collagen. It had been shown that beta-aminopropionitrile blocks the cross-linkage of elastin and collagen by preventing the initial step in cross-linkage: the conversion of lysine in peptide linkage to agr-amino adipic-dgr-semialdehyde. We show that penicillamine acts after the initial step, causing the accumulation of an elastin rich in agr-amino adipic-dgr-semialdehyde.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Covalent Binding of Rofecoxib, but Not Other Cyclooxygenase-2 Inhibitors, to Allysine Aldehyde in Elastin of Human Aorta.
M. Oitate, T. Hirota, T. Murai, S.-i. Miura, and T. Ikeda (2007)
Drug Metab. Dispos. 35, 1846-1852
   Abstract »    Full Text »    PDF »
Mechanism for Covalent Binding of Rofecoxib to Elastin of Rat Aorta.
M. Oitate, T. Hirota, M. Takahashi, T. Murai, S.-i. Miura, A. Senoo, T. Hosokawa, T. Oonishi, and T. Ikeda (2007)
J. Pharmacol. Exp. Ther. 320, 1195-1203
   Abstract »    Full Text »    PDF »
Transplantation Antigens.
B. D. Kahan and R. A. Reisfeld (1969)
Science 164, 514-521
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)