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Science 2 August 1968:
Vol. 161. no. 3840, pp. 465 - 467
DOI: 10.1126/science.161.3840.465
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Articles

Interferon Inducers in vitro: Difference in Sensitivity to Inhibitors of RNA and Protein Synthesis

Martin S. Finkelstein 1, Gerald H. Bausek 1, and Thomas C. Merigan 1

1 Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304

Interferon can be induced by diverse agents in a variety of mammalian cell cultures through apparently two mechanisms. One results in an early (2 to 10 hours) appearance of interferon and is relatively resistant to inhibition by actinomycin, puromycin, or fluorophenylalanine. A second mechanism results in a late (18 to 24 hours) appearance of interferon and is more sensitive to inhibition by these inhibitors. The molecular basis for each mechanism is unclear. Since each interferon inducer may have multiple effects on the cell, the differences observed may not necessarily reflect a fundamental difference in the mechanism of interferon stimulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction of Interferon by Nonviral Agents.
E. De Clercq and T. C. Merigan (1970)
Arch Intern Med 126, 94-108
   Abstract »    PDF »
Double-Stranded RNAs (Poly I:C) in the Prevention of Viral Infections.
M. R. Hilleman (1970)
Arch Intern Med 126, 109-124
   Abstract »    PDF »
Interferon Induction Increased through Chemical Modification of a Synthetic Polyribonucleotide.
E. D. Clercq, F. Eckstein, and T. C. Merigan (1969)
Science 165, 1137-1139
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)