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Science 19 July 1968:
Vol. 161. no. 3838, pp. 280 - 281
DOI: 10.1126/science.161.3838.280
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Articles

4-Leucine-Oxytocin: Natriuretic, Diuretic, and Antivasopressin Polypeptide

W. Y. Chan 1, Victor J. Hruby 1, George Flouret 1, and Vincent du Vigneaud 1

1 Departments of Pharmacology and Biochemistry, Cornell University Medical College, New York 10021 and Department of Chemistry, Cornell University, Ithaca, New York

During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance.


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