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Science 5 July 1968:
Vol. 161. no. 3836, pp. 72 - 73
DOI: 10.1126/science.161.3836.72
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Articles

Genetic Control of Drug Levels in Man: Antipyrine

Elliot S. Vesell 1 and John G. Page 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland 20014

Antipyrine was administered to identical or monozygotic twins and to fraternal or dizygotic twins. Individuals with identical genotypes (monozygotic twins) exhibited significantly less variability in antipyrine halflife than did genetically different individuals (dizygotic twins). Therefore variations in antipyrine metabolism appear to be determined genetically rather than environmentally. In the 36 twins tested, antipyrine half-lives varied between 5.1 and 16.7 hours. No significant correlation occurred between half-lives for phenylbutazone and antipyrine in the 28 twins who received both drugs.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)