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Science 5 July 1968:
Vol. 161. no. 3836, pp. 57 - 59
DOI: 10.1126/science.161.3836.57
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Articles

Cyclic 3',5'-Adenosine Monophosphate Phosphodiesterase Produced by the Slime Mold Dictyostelium discoideum

Ying-Ying Chang 1

1 Department of Biology, Princeton University, Princeton, New Jersey 08540

An enzyme that hydrolyzes cyclic ',5'-adenosine monophosphate to 5'-adenosine monophosphate was found in the culture medium of the cellular slime mold Dictyostelium discoidum. The enzymatic activity shows a pH optimum of 7.5, and magnesium is required for maximum activity. The enzyme is not inhibited by caffeine. It has a Michaelis-Menten constant of 2 x 10-3M and its molecular weight is around 300,000.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adenosine 3', 5'-Monophosphate Phosphodiesterase in the Growth Medium of Physarum polycephalum.
A. W. Murray, M. Spiszman, and D. E. Atkinson (1971)
Science 171, 496-498
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Science. ISSN 0036-8075 (print), 1095-9203 (online)