Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 5 July 1968:
Vol. 161. no. 3836, pp. 54 - 56
DOI: 10.1126/science.161.3836.54
Prev | Table of Contents | Next

Articles

Transplantation of Marrow to Extramedullary Sites

Mehdi Tavassoli 1 and William H. Crosby 1

1 Blood Research Laboratory, Tufts-New England Medical Center, Boston, Massachusetts 02111

Autologous fragments of transplanted marrow have survived in various extramedullary sites in the rat, rabbit, and dog. Survival of the fragments occurs with a complete reconstitution of the hemopoietic and adventitial structures. The process originates from a network of surviving reticular cells which proliferate and differentiate into osteoblasts and give rise to trabecular bone. Later, the reticular cells reconstruct the marrow's microcirculation. Hemopoietic repopulation of the marrow implant takes place only after its sinusoidal microcirculation has been established.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bone Cells, Osteoprogenitors, and Hematopoiesis.
P. Bianco (2008)
IBMS BoneKEy 5, 269-274
   Abstract »    Full Text »    PDF »
Close Encounters of the Bone-Blood Kind.
J. E. Aubin (2008)
IBMS BoneKEy 5, 25-29
   Full Text »    PDF »
Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow.
S. Gronthos, A. C. W. Zannettino, S. J. Hay, S. Shi, S. E. Graves, A. Kortesidis, and P. J. Simmons (2003)
J. Cell Sci. 116, 1827-1835
   Abstract »    Full Text »    PDF »
Implantation of bone marrow beneath the kidney capsule results in transfer not only of functional stroma but also of hematopoietic repopulating cells.
F. Varas, T. Grande, A. Ramirez, and J. A. Bueren (2000)
Blood 96, 2307-2309
   Abstract »    Full Text »    PDF »
Bone Marrow Curettage in Myelodysplastic Disorders: A Stimulus for Regeneration in Disturbed Hematopoiesis.
Y. Matzner and A. Polliack (1981)
JAMA 246, 1926-1928
   Abstract »    PDF »
Bone Marrow Histogenesis: A Comparison of Fatty and Red Marrow.
M. Tavassoli and W. H. Crosby (1970)
Science 169, 291-293
   Abstract »    PDF »
Origin of Repopulating Cells after Localized Bone Marrow Depletion.
M. A. Maloney and H. M. Patt (1969)
Science 165, 71-73
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)