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Science 28 June 1968:
Vol. 160. no. 3835, pp. 1463 - 1465
DOI: 10.1126/science.160.3835.1463
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Articles

Rejection of Renal Allografts: Specific Immunologic Suppression

Frank P. Stuart 1, Tatsuo Saitoh 1, and Frank W. Fitch 1

1 Departments of Surgery and Pathology, University of Chicago, Chicago, Illinois 60637

Kidneys were transplanted across a major genetic barrier (Ag-B locus), from LewisxBN F1 hybrid rats into bilaterally nephrectomized Lewis rats. Survival of grafts is prolonged (indefinite?) in rats treated with a combination of (i) intravenous injection of donor spleen cells 1 day before the graft, and (ii) passive immunization with antiserum prepared in rats of the recipient strain against donor spleen and lymph-node cells. The recipient's immune response to other antigens is not impaired.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Specific Suppression of Immune Responses.
D. A. Rowley, F. W. Fitch, F. P. Stuart, H. Kohler, and H. Cosenza (1973)
Science 181, 1133-1141
   Abstract »    PDF »
Inhibition of Renal Allograft Rejection: Instances in Dogs With Specific Enhancing Immunoglobulin and Its Proteolytic Fragments.
R. H. Yonemoto, R. M. Deliman, W. D. DuSold, and T. Hamilton (1973)
Arch Surg 107, 390-394
   Abstract »    PDF »
In Vivo and in Vitro Studies of Cardiac Allografts in the Rat: Immunological Enhancement.
S. G. Souther, R. O. Gordon, J. J. Oppenheim, and E. B. Stinson (1972)
Arch Surg 105, 756-760
   Abstract »    PDF »
Graft Rejection.
J. D. Feldman (1969)
Arch Intern Med 123, 713-718
   Abstract »    PDF »
Hypersensitivity: Specific Immunologic Suppression of the Delayed Type.
M. Axelrad and D. A. Rowley (1968)
Science 160, 1465-1467
   Abstract »    PDF »


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