Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 June 1968:
Vol. 160. no. 3835, pp. 1451 - 1452
DOI: 10.1126/science.160.3835.1451
Prev | Table of Contents | Next

Articles

Photodimer of Thymine in Ultraviolet-Irradiated DNA: Proof of Structure by X-ray Diffraction

Norman Camerman 1 and Arthur Camerman 2

1 Department of Chemistry, University of Toronto, Toronto 5, Canada
2 Department of Biological Structure, University of Washington, Seattle, Washington 98105

Dimethylthymine was photodimerized with ultraviolet radiation, and the structure of one of the resulting dimers, the cis 5,5 : 6,6 isomer, was determined by single-crystal x-ray diffraction. This isomer is the same as that obtained by ultraviolet irradiation of DNA; hence the structure of the thymine dimer in irradiated DNA is now proved.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alteration of DNA Tertiary Structure by Physical and Chemical Carcinogens: Involvement in DNA Repair Processes.
S. Spadari, B. M. Sutherland, G. Pedrali-Noy, F. Focher, M. T. Chiesa, and G. Ciarrocchi (1987)
Toxicol Pathol 15, 82-87
   Abstract »    PDF »
Altered Structure of Ultraviolet-irradiated DNA: Evidence for Unwinding.
H.J. Edenberg (1983)
Cold Spring Harb Symp Quant Biol 47, 379-382
   Abstract »    PDF »
Crystal and Molecular Structure of a Thymine Phototrimer.
J. L. Flippen, I. L. Karle, and S. Y. Wang (1970)
Science 169, 1084-1085
   Abstract »    PDF »
Crystal and Molecular Structure of a Thymine-Thymine Adduct.
I. L. Karle, S. Y. Wang, and A. J. Varghese (1969)
Science 164, 183-184
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)