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Science 21 June 1968:
Vol. 160. no. 3834, pp. 1361 - 1363
DOI: 10.1126/science.160.3834.1361
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Articles

Sleep Patterns of the Monkey and Brain Serotonin Concentration: Effect of p-Chlorophenylalanine

Elliot D. Weitzman 1, Maurice M. Rapport 2, Peter McGregor 3, and Jack Jacoby 3

1 Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York
2 New York State Psychiatric Institute, New York, New York
3 Saul R. Korey Department of Neurology

The amount of time that monkeys (Macaca mulatta) slept was reduced after they were given p-chlorophenylalanine, a selective depletor of serotonin in animal tissues. The time spent in the rapid eye movement stage of sleep was unchanged, but the time in other sleep stages decreased. Seven regions of the brain had a 31 to 46 percent decrease in serotonin content; the concentration of cerebellar serotonin increased by 44 percent.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Social Behavior of Monkeys Selectively Depleted of Monoamines.
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Serotonin Now: Clinical Implications of Inhibiting Its Synthesis with Para-Chlorophenylalanine.
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