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Science 14 June 1968:
Vol. 160. no. 3833, pp. 1246 - 1248
DOI: 10.1126/science.160.3833.1246
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Articles

LSD in Mice: Abnormalities in Meiotic Chromosomes

N. E. Skakkebæk 1, J. Philip 1, and O. J. Rafaelsen 2

1 Cytogenetic Laboratory, Department of Obstetrics and Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
2 Psychochemical Laboratory, Department of Psychiatry, Rigshospitalet

Meiotic chromosomes of six mice injected with high doses of lysergic acid diethylamide (LSD-25) and of six controls were studied. Several breaks, gaps, and unidentifiable fragments were found in the treated but, with a few exceptions, not in the control animals. Secondary constrictions were more numerous in the treated than in the untreated mice. Possible consequences are discussed.


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