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Science 14 June 1968:
Vol. 160. no. 3833, pp. 1240 - 1241
DOI: 10.1126/science.160.3833.1240
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Articles

Secretory Immunoglobulin A: Autoantibody Activity in Gastric Juice

Leonard S. Goldberg 1, Joseph Shuster 1, Margaret Stuckey 1, and H. Hugh Fudenberg 1

1 Section of Hemtiatology, and Immunology, Department of Medicine, University of California, San Francisco Medical Center, San Francisco

An immunoglobulin A of the secretory variety, present in the gastric juice of a patient with pernicious anemia, was shown to have specificity for intrinsic factor. This is the first demonstration in gastric juice of antibody activity restricted to secretory IgA; further, this is the first example of an exocrine (gastric) immune system producing an autoantibody specifically directed toward a product synthesized by that same exocrine organ.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human Autoimmunity, with Pernicious Anemia as a Model.
L. S. GOLDBERG, R. BLUESTONE, E. R. STIEHM, P. I. TERASAKI, and R. H. WEISBART (1974)
Ann Intern Med 81, 372-380
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Science. ISSN 0036-8075 (print), 1095-9203 (online)