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Science 14 June 1968:
Vol. 160. no. 3833, pp. 1237 - 1239
DOI: 10.1126/science.160.3833.1237

Articles

Motor Effects of Copper in the Caudate Nucleus: Reversible Lesions with Ion-Exchange Resin Beads

Larry L. Butcher 1 and Stephen S. Fox 1

1 Department of Psychology and Mental Health Research Institute, University of Michigan, Ann Arbor

A method employing the use of ion-exchange resin beads is described for the punctate introduction of discrete amounts of various anions, cations, or zwitterions into given brain regions. A series of experiments utilizing the method to introduce ionic copper into the caudate nucleus with the resulting motor manifestations are discussed.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)