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Science 14 June 1968:
Vol. 160. no. 3833, pp. 1233 - 1234
DOI: 10.1126/science.160.3833.1233
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Articles

Primaquine-Induced Changes in Morphology of Exoerythrocytic Stages of Malaria

Richard L. Beaudoin 1 and Masamichi Aikawa 2

1 Department of Parasitology, Naval Medical Research Institute, Bethesda, Maryland 20014
2 Department of Experinmental Pathology, Walter Reed Army Institute of Research, Washington, D.C. 20012

Exposure to primaquine for 48 hours caused lesions in the exoerythrocytic stages of Plasmodium fallax grown in cultivated cells derived from embryonic turkey brain. The lesions appeared in the form of cytoplasmic vacuoles when viewed under the light microscope. The electron microscope revealed these vacuoles as swollen mitochondria readily identifiable by their typical protozoan cristae. Mitochondria of the host cell were unaffected.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)