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Science 7 June 1968:
Vol. 160. no. 3832, pp. 1112 - 1113
DOI: 10.1126/science.160.3832.1112
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Articles

Prevention of Radiation-Induced Creatinuria by Insulin

Thomas R. Koszalka 1 and Carole L. Andrew 1

1 Departments of Radiology and Biochemistry, Jefferson Medical College, Philadelphia, Pennsylvania

Insulin completely suppressed creatinuria in rats x-irradiated with an absorbed dose of 500 rads. The hormone may exert this effect either by restoring or maintaining the ability of irradiated muscle to take up creatine from the extra-cellular fluid at a normal rate, or possibly by influencing the synthesis or breakdown of phosphorylcreatine.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)