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Science 31 May 1968:
Vol. 160. no. 3831, pp. 1014 - 1017
DOI: 10.1126/science.160.3831.1014
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Articles

Mixed Lymphocyte Reaction: An in vitro Test for Antilymphocytic Serum Activity

M. Roy Schwarz 1, R. W. Tyler 1, and N. B. Everett 1

1 Department of Biological Structure, University of Washington, Seattle

When Lewis rats were exposed to antilymphocytic serum, produced in rabbits, to Lewis lymphoid cells, the transformation of their thoracic duct lymphocytes in response to foreign lymphoid cells was markedly reduced in comparison with that in response to similar cells from donors treated with saline or normal rabbit serum. It is suggested that the mixed lymphocyte reaction may be used as an in vitro test for the in vivo activity of antilymphocytic serum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antilymphocytic Antibody: Effects in Experimental Animals and Problems in Human Use.
S. SELL (1969)
Ann Intern Med 71, 177-196
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