Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 31 May 1968:
Vol. 160. no. 3831, pp. 1009 - 1010
DOI: 10.1126/science.160.3831.1009
Prev | Table of Contents | Next

Articles

3-Acetylpyridine: Effects in vitro Related to Teratogenic Activity in Chicken Embryos

Arnold I. Caplan 1, Edgar Zwilling 1, and Nathan O. Kaplan 1

1 Department of Biology and Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02154

Production of skeletal muscle hypoplasia by 3-acetylpyridine and its complete reversal by nicotinamide in developing chicken embryos have been confirmed. Cultures of developing embryonic chicken muscle show degenerative effects produced by 3-acetylpyridine; these effects are reversed by nicotinamide. Cartilage production in cultured chondrogenic cells is potentiated by 3-acetylpyridine; this potentiation is completely reversed by nicotinamide. It is suggested that nicotinamide-or pyridine-nucleotide-dependent reactions influence normal differentiation of limb mesoderm cells by inhibiting chondrogenic-cell and potentiating muscle-cell expression or proliferation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chemical Messengers in Development: A Hypothesis.
D. McMahon (1974)
Science 185, 1012-1021
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)