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Science 24 May 1968:
Vol. 160. no. 3830, pp. 899 - 900
DOI: 10.1126/science.160.3830.899
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Articles

Caudate Unit Responses to Nigral Stimuli: Evidence for a Possible Nigro-Neostriatal Pathway

John D. Connor 1

1 St. Elizabeths Hospital, National Institute of Mental Health, Washington, D.C. 20032

Electrical stimulation of the Substantia nigra evokes depressant and facilitatory responses from individually recorded caudate nucleus neurons. These effects resemble those elicited from caudate cells by microiontophoretic ejections of dopamine. Since histochemical evidence suggests that dopamine-containing fibers link the substantia nigra with the caudate, this pathway may mediate the changes in caudate spike rates produced by nigral stimuli.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)