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Science 24 May 1968:
Vol. 160. no. 3830, pp. 885 - 886
DOI: 10.1126/science.160.3830.885
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Articles

Fetal Hemoglobin Variants in Mice

John G. Gilman 1 and Oliver Smithies 1

1 Laboratory of Genetics, University of Wisconsin, Madison 53706

Two strains of mice, DBA and C3H, have a fetal globin polypeptide chain which differs in electrophoretic mobility from the corresponding fetal chain of the C57B1 strain. Mice of the DBA and C3H strains also differ from those of the C57B1 in adult hemoglobin type. Results of backcrossing the (DBA x C57B1) hybrid to the C57B1 suggest that the fetal chain locus and the adult beta-chain locus are closely linked.


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