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Science 17 May 1968:
Vol. 160. no. 3829, pp. 795 - 796
DOI: 10.1126/science.160.3829.795
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Articles

Macrophage Spreading: Inhibition in Delayed Hypersensitivity

Robert M. Fauve 1 and Dragan Dekaris 1

1 Institut Pasteur, 92 - Garches, France

The capacity of peritoneal macrophages to spread was studied with cells of mice infected with Listeria monocytogenes and with cells of guinea pigs sensitized with BCG (bacille Calmette Guérin) vaccine or immunized with ovalbumin. In macrophages taken from animals having delayed hypersensitivity, this ability was markedly decreased by the presence of specific antigen for less than 1 hour. Such an effect was not observed in guinea pigs having only circulating antibodies.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)